Journal article
Promises and Pitfalls of Metal Imaging in Biology
EJ New, VC Wimmer, DJ Hare
Cell Chemical Biology | CELL PRESS | Published : 2018
Abstract
A picture may speak a thousand words, but if those words fail to form a coherent sentence there is little to be learned. As cutting-edge imaging technology now provides us the tools to decipher the multitude of roles played by metals and metalloids in molecular, cellular, and developmental biology, as well as health and disease, it is time to reflect on the advances made in imaging, the limitations discovered, and the future of a burgeoning field. In this Perspective, the current state of the art is discussed from a self-imposed contrarian position, as we not only highlight the major advances made over the years but use them as teachable moments to zoom in on challenges that remain to be ove..
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Awarded by Westpac Bicentennial Foundation
Funding Acknowledgements
E.J.N. acknowledges the Westpac Bicentennial Foundation for a Research Fellowship and the Australian Research Council (DP150100649 and DP150103369). D.J.H. is funded by an Australian National Health and Medical Research Council Career Development Fellowship in partnership with Agilent Technologies (1122981). He is also supported by an Australian Research Council Linkage Project with Agilent Technologies and ESI Ltd (LP120200081). The Florey Institute of Neuroscience and Mental Health acknowledges the Operational Infrastructure Support from the Victorian State Government. We wish to thank Dr Simon James for providing photographs used in Figure 3.